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What Differences Are Between the Five Corona Virus Mutations That Worry the World?

What Differences Are Between the Five Corona Virus Mutations That Worry the World?

At least five new types of the new type of corona virus keep scientists up at night. Detected in the southeast of England, the B117 variation has been seen in at least 60 countries so far. The researchers explained that the mutation in question spread 50-70 percent faster. Other mutations originating in South Africa, Brazil, the USA and Germany did not spread as rapidly as B117, but they do show a number of mutations that have caught the attention of geneticists.

As a molecular immunologist at Rockefeller University, Dr. "To be honest, we haven't gotten much sleep lately. But so far, none of the mutations have done what scientists fear most and mutated enough to cause more serious illness. But we continue to study them all the time," said Christian Gerber.

Here are five mutations that scientists constantly watch ...

UK: B117
At the top of the list for scientists is the B177 mutation, which was first seen in the UK. The US Centers for Disease Control and Prevention (CDC) warned that the variant that spread to more than 60 countries last week could worsen the spread of the pandemic. A previous study by London College University in England found that B117 is 50-70 percent more contagious. However, Gregory Armstrong, who leads the Office of Advanced Molecular Monitoring at the CDC, told CNN, "The mutant virus does not cause severe disease, although it appears to spread faster. According to our current observations, it is decisive in hospitalization or death rates. "There is no increase."

On the other hand, 17 genetic changes occurred in the B117 variant, including the spike protein to which the corona virus attaches to human cells. This means that mutations in the variant more easily enter the ACE2 receptors on the outer surface of the lungs, arteries, heart, kidneys and intestines. This leads to a higher probability of these particles infecting some cells in the sinuses or lungs if the air, which are corona virus particles, is inhaled.

Armstrong stated that the evidence that B117 is more easily transmitted is quite strong, “Approximately 11 out of 100 people who come into contact with someone infected with previous virus types become infected. However, 16 out of every 100 people who come into contact with someone with the B117 mutation are infected. Also, there is evidence that people infected with the B117 variant have higher viral loads. Therefore, it makes sense that the variant is more easily transmitted to humans because viruses invade the cells they infect and turn them into virus factories. "More infected cells means more viruses."

Much more physical changes occurred in the protein structure of the variant, named B.1.351 or 501Y.V2, first seen in South Africa than in the UK. In particular, an important change called E484K affected a significant part of the spike protein used by the corona virus to bind to cells. The researchers therefore believe that B.1.351 may partially reduce the effectiveness of vaccines. Commenting on the subject, Armstrong said, "The South African mutation is more concerned than other variants. Vaccine manufacturers and academic researchers are testing samples of this variant with others to see that it cannot survive the immune response caused by the mutant virus."

On the other hand, Doctor Michel Nussenzweig of Rockefeller University does not think so. Nussenzweig and colleagues are working on the immune response to corona virus infection. The human body has produced hundreds of different antibodies to attack the South African mutation, according to the study published by the team in the journal Nature Monday. In the study, it was stated that people's immune response matured and got even better at targeting the virus.

"We have a pre-built reservoir of antibodies. The immune system goes into that pool and sees what fits well. Once it finds these antibodies, it can refine them and make them even better. Vaccines produce an immune response similar to natural infection. So, the immune response is an immune response," says Nussenzweig. "Even if a new variant emerges with mutations that allow it to bypass the part of it, the body produces antibodies that can see the non-hidden parts of the virus," he stressed that people should not worry about the mutation.

Two weeks ago, two mutations of the new type of corona virus, S.1 and S.2, were detected in Brazil. In a study conducted in Manaus, the capital of the Amazon, the P1 mutation was detected in 42 percent of the samples. 4 people from Brazil in Japan, the same varya

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